Crosstalk between TGF-β1 and complement activation augments epithelial injury...
The epithelial complement inhibitory proteins (CIPs) cluster of differentiation 46 and 55 (CD46 and CD55) regulate circulating immune complex-mediated complement activation in idiopathic pulmonary...
View ArticleCo-ordinated expression of innate immune molecules during mouse neurulation
The innate immune system is the first line of defence against pathogens and infection. Recently, it has become apparent that many innate immune factors have roles outside of immunity and there is...
View ArticleContribution of the anaphylatoxin receptors, C3aR and C5aR, to the...
Complement activation, an integral arm of innate immunity, may be the critical link to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Whereas we have previously reported elevated...
View ArticleComplement mediators in ischemia-reperfusion injury
Background: Ischemia-reperfusion (I/R) injury occurs when a tissue is temporarily deprived of blood supply and the return of the blood supply triggers an intense inflammatory response. Pathologically,...
View ArticleComplement in the fundamental processes of the cell
Once regarded solely as an activator of innate immunity, it is now clear that the complement system acts in an assortment of cells and tissues, with immunity only one facet of a diverse array of...
View ArticleComplement in pregnancy: a delicate balance
The complement system is a key component of innate host defence that, under normal conditions, is responsible for the opsonization and destruction of potential pathogens. However, inappropriate or...
View ArticleComplement inhibitors selectively attenuate injury following administration...
Systemic activation of complement is a pathophysiological response common to severe disturbances such as hemorrhagic shock, major burn injury and sepsis. Intravenous infusion of cobra venom factor...
View ArticleComplement factors C3a and C5a have distinct hemodynamic effects in the rat
In the rat, C5a infusion mediates well-defined effects including hypotension and neutropenia. Conversely, the comparative effect of C3a in the rat is not yet defined. In the current study, we have...
View ArticleComplement factor C5a as mast cell activator mediates vascular remodelling in...
Failure of vein graft conduits due to vein graft thickening, accelerated atherosclerosis, and subsequent plaque rupture is applicable to 50 of all vein grafts within 10 years. New potential therapeutic...
View ArticleComplement factor 5a as a therapeutic target
The complement system is an innate immune defense mechanism that protects the host from infection and injury. Complement activation results in the formation of anaphylatoxins, including the...
View ArticleComplement component 5a (C5a)
The 74 amino acid glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzymatically from its precursor, C5, upon activation of the complement cascade. C5a is...
View ArticleComplement C5a regulates prolabor mediators in human placenta
Human preterm and term parturition is associated with inflammatory cascades in the uteroplacental unit. Activation of the complement cascade releases potent proinflammatory mediators, including the...
View ArticleComplement C5aR1 signaling promotes polarization and proliferation of...
The complement system, typically associated with innate immunity, is emerging as a key controller of nonimmune systems including in development, with recent studies linking complement mutations with...
View ArticleComplement C5a inhibition reduces atherosclerosis in ApoE(-/-) mice
The complement C5a receptor, CD88, is present on many of the cells found within human atherosclerotic plaques, but little is known about the role of C5a in atherogenesis. Using real-time PCR, we...
View ArticleComplement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment...
Background: The terminal pathway of the innate immune complement system is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Terminal complement activation leads to generation of...
View ArticleComplement activation in the injured central nervous system: Another...
The complement system, a major component of the innate immune system, is becoming increasingly recognised as a key participant in physiology and disease. The awareness that immunological mediators...
View ArticleComparative efficacy of a secretory phospholipase A(2) inhibitor with...
Introduction: Previously, secretory phospholipase A(2) (sPLA(2)) inhibition has been used as an adjunct to conventional rheumatoid arthritis therapy in human clinical trials without significant...
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